Selective and oxidative stress-mediated cell death of MCF-7 cell line induced by terpinolene

In this study, we compared the effects of terpinolene against anti-cancer agent cisplatin on proliferation, apoptotic activity and intracellular ROS (reactive oxygen species) production in cancerous (MCF-7) non-cancerous (HEK-293) cell lines. Cisplatin presented a strong growth-inhibitory effect both MCF-7 (IC25: 18.77 µM) HEK-293 15.03 The was found to be weaker than 291.18 µM for 345.35 HEK 293 cells). expression levels BAX (by 1.86-fold), cleaved-PARP 2.23-fold) pro-caspase-8 1.74-fold) proteins increased response treatment cells. Curiously, increase these markers less pronounced terpinolene-treated Terpinolene, promoted higher rate necrotic death cells (apoptotic cells: 25.28 %; 17.70 %) when with line 15.47 9.42 %). Interestingly, caused marked (2.05-fold) while appeared resistant or treatments. conclusion, although showed cancer cells, it exhibited better selectivity inducing oxidative stress MCF7 breast